Retinoblastoma Progression
نویسنده
چکیده
The Vision Center, Division of Pediatric Ophthalmology, Department of Surgery, and The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, United States USC Eye Institute, Department of Ophthalmology, and Norris Comprehensive Cancer Center, Keck School ofMedicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, United States
منابع مشابه
A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system
Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors including RB. However, RB treatment by targeting EGFR has not yet been researched. In the current study, we investigated the effect of EGFR down-regula...
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Retinoblastoma is a pediatric retinal tumor initiated by biallelic inactivation of the retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the abundance of work demonstrating the molecular function and identifying binding partners of pRb, t...
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